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FMD virus is extremely sensitive to pH. Virus survival
is optimal between pH 7.2 and 7.6. At pHs above 9 and below 6 the
virus is rapidly destroyed. For this reason either acids (e.g., citric
acid) or bases (e.g., caustic soda or sodium carbonate) are effective
at inactivating the virus, particularly in combination with detergents
to ensure penetration of organic material. At higher temperatures
the effect of pH on virus survival is increased whereas at low temperatures
it is reduced.
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